Zejula Maintenance Therapy Extends Survival With Toxicities in Recurrent Ovarian Cancer

Patients with recurrent ovarian cancer who received Zejula (niraparib) maintenance therapy experienced more time without symptoms or toxicity compared with placebo, according to results from the phase 3 ENGOT-OV16/NOVA trial.

“This TWiST (time without symptoms or toxicity) analysis benefit means that patients treated with niraparib experienced more progression-free time without symptoms or toxicities due to nausea, vomiting, or fatigue compared to placebo,” Ursula A. Matulonis, M.D., director and chief of gynecologic oncology at Dana-Farber Cancer Institute, said during her presentation at the 50th SGO Annual Meeting, held March 16-19 in Honolulu, Hawaii.

In the multicenter, double-blind, randomized-controlled trial, patients with recurrent ovarian cancer who were in response to their last platinum-based chemotherapy were randomly assigned to receive either 300 mg of Zejula once daily as a maintenance treatment – including 138 patients in the germline BRCA-mutated cohort and 234 in the non-germline group – or placebo – made up of 65 patients in the germline BRCA-mutated cohort and 116 in the non-germline group.


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Posted in Research.